Anti-β-arrestin 1抗體，β-抑制蛋白1抗體產品詳細資料

產品編號 BYK-0857R

英文名稱 beta-arrestin 1 + beta-arrestin 2
中文名稱 β-抑制蛋白1抗體
別    名 Beta arrestin 1; ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin beta 1; ARRB1_HUMAN; Arrestin 2; Arrestin beta-1; Beta-arrestin-1; Beta-arrestin 2; Beta Arrestin 2; ARB 2; ARB2; ARR 2; ARR2; ARRB 2; ARRB2; ARRB2_HUMAN; Arrestin 3; Arrestin beta 2; Arrestin beta-2; BARR2; DKFZp686L0365; HGNC:712; Beta-arrestin-2.
研究領域 神經生物學  信號轉導  生長因子和激素  激酶和磷酸酶  通道蛋白  細胞膜受體  G蛋白偶聯受體  
分 子 量 45kDa

抗體來源 Mouse or Rabbit
克隆類型 Monoclonal or Polyclonal
產品應用 WB、ELISA、IHC-P、IHC-F、Flow-Cyt、IF、IP、ICC 此產品應用不做依據，具體產品應用與實驗稀釋比請！

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.


     Anti-β-arrestin 1抗體，β-抑制蛋白1抗體產品介紹 

      Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway. 

 此相關標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記 

     相關產品：

     Anti-FBXO33抗體,F-box蛋白相關蛋白33抗體

Anti-FBXO11抗體,F-box蛋白相關蛋白11抗體
Anti-FBXL20抗體,FBXL20蛋白抗體
Anti-FBXL16抗體,FBXL16蛋白抗體
Anti-FBXL21抗體,FBXL21蛋白抗體
Anti-FBXO7抗體,F-box蛋白家族FBXO7抗體
Anti-FBXO11抗體,F-box蛋白家族FBXO11抗體
Anti-FBXO25抗體,F-box蛋白家族FBXO25抗體
Anti-FBXO18抗體,F-box蛋白家族FBXO18抗體
Anti-Factor IX抗體,*9抗體
Anti-Factor X抗體,*10抗體
Anti-Factor XI light chain抗體,*11輕鏈抗體
Anti-Factor XII heavy chain抗體,*12重鏈抗體
Anti-Factor H抗體,補體因子H抗體
Anti-FAM135B抗體,FAM135B蛋白抗體
Anti-FAM166A抗體,FAM166A蛋白抗體
Anti-FBXW5抗體,FBXW5蛋白抗體
Anti-FBXW12抗體,FBXW12蛋白抗體
Anti-FBXO42抗體,FBXO42蛋白抗體